N,N′-Dimethyl Urea
Synlett
DOI: 10.1055/s-0029-1219573
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | FREE: Full text
Archive for the 'Synlett' Category
Benzyltriphenylphosphonium Peroxymonosulfate
Synlett
DOI: 10.1055/s-0029-1219570
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | FREE: Full text
The First One-Pot Synthesis of Morita-Baylis-Hillman Adducts Starting Directly from Alcohols
Synlett
DOI: 10.1055/s-0029-1219577
Abstract
The first example of one-pot oxidative carbon-carbon bond
formation via the Morita-Baylis-Hillman reaction
using alcohols is reported. The protocol involves silica gel-DABCO
catalyzed oxidation of alcohols to aldehydes with chloramine-T followed
by their Morita-Baylis-Hillman reaction with acrylonitrile
or methyl acrylate to give 70-87% overall yields
of the corresponding Morita-Baylis-Hillman
adducts. The present work opens up a new and efficient synthetic
route to Morita-Baylis-Hillman adducts directly
from alcohols in a one-pot operation.
[...]
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | Abstract | Full text
New Electrophilic Bromodifluoromethylation and Pentafluoroethylation Reagents
Synlett
DOI: 10.1055/s-0029-1219579
Abstract
-(fluoroalkyl)diphenylsulfonium salts
have been successfully synthesized from the reaction between fluoroalkylsulfinates
and triflic anhydride in dichloromethane through a one-pot procedure.
These (fluoroalkyl)diphenylsulfonium
salts have been demonstrated to be effective reagents to fluoroalkylate
C-nucleophilic substrates. Ionic substitution and radical or halogenophilic mechanism
might be all involved in the reactions.
[...]
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | Abstract | Full text
Synthesis of N-Arylisoindolin-1-ones via Pd-Catalyzed Intramolecular Decarbonylative Coupling of N-(2-Bromobenzyl)oxanilic Acid Phenyl Esters
Synlett
DOI: 10.1055/s-0029-1219580
Abstract
Ethyl and phenyl oxanilates were readily prepared from -(2-bromobenzyl)anilines and oxalyl
chloride monoethyl and monophenyl esters, respectively. It was found
that the ethyl oxanilate survived in the presence of KCO in
DMA at 120 ˚C and underwent an intramolecular direct arylation
using Pd(OAc)-dppf, furnishing the 5,6-dihydrophenanthridine
derivative. In contrast, the corresponding phenyl oxanilates decomposed
upon exposure to KCO in DMA at 120 ˚C
and were transformed into -arylisoindolin-1-ones
via Pd(OAc)-dppf-catalyzed intramolecular decarbonylative
coupling. Except for the 4-methoxy-substituted oxanilic acid phenyl
ester, other phenyl oxanilates possessing electron-withdrawing (NO,
Cl) and weak electron-donating (Me) substituents provided the -arylisoindolin-1-ones in 43-80% yields.
[...]
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | Abstract | Full text
Metal-Free One-Pot Conversion of Electron-Rich Aromatics into Aromatic Nitriles
Synlett
DOI: 10.1055/s-0029-1219575
Abstract
Various electron-rich aromatics could be smoothly converted into
the corresponding aromatic nitriles in good to moderate yields by
treatment of electron-rich aromatics with POCl and DMF,
followed by treatment with molecular iodine in aqueous ammonia.
The present reaction is a novel metal-free one-pot method for the
preparation of aromatic nitriles from electron-rich aromatics.
[...]
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | Abstract | Full text
Highly Enantioselective and Regioselective Conjugate Addition of Nitromethane to 1,5-Diarylpenta-2,4-dien-1-ones Using Bifunctional Cinchona Organocatalysts
Synlett
DOI: 10.1055/s-0029-1219576
Abstract
A general and efficient asymmetric organocatalytic 1,4-Michael
addition of nitromethane to 1,5-diarylpenta-2,4-dien-1-ones (cinnamylideneacetophenones)
catalyzed by 9-thiourea-9-(deoxy)–hydroquinine
has been developed. The reactions afforded excellent enantioselectivities
(up to 99%), high yields (up to 97%), and exclusive
regioselectivity.
[...]
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | Abstract | Full text
A Practical Synthesis of (S)-Cyclopent-2-enol
Synlett null; null: 840-840
DOI: 10.1055/s-0029-1219555
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | FREE: Full text
Chemistry of Lactam-Derived Vinyl Phosphates: Stereoselective Synthesis of (+)-Fagomine
Synlett null; null: 839-839
DOI: 10.1055/s-0029-1219556
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | FREE: Full text
An Efficient and Short Synthesis of 4-Aryl-3-methyltetrahydroquinolines from N-Benzylanilines and Propenylbenzenes through Cationic Imino Diels-Alder Reactions
Synlett
DOI: 10.1055/s-0029-1219571
Abstract
A new, simple protocol for the BF˙OEt-catalyzed
synthesis of diverse 3-methyl-4-aryl-1,2,3,4-tetrahydroquinolines using
easily available starting materials and renewable phenylpropenoid
reagents is described. These compounds could serve as interesting
models in pharmacological studies.
[...]
© Georg Thieme Verlag
Stuttgart ˙ New York
Get connected:
Table of contents | Abstract | Full text
