Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water
Synlett
DOI: 10.1055/s-0029-1217529
Abstract
A novel methodology for the synthesis of 2-amino-4-aryl(alkyl)-6-sulfanyl
pyridine-3,5-dicarbonitriles via a one-pot, three-component reaction
of structurally diversified aldehydes with various -alkylisothiouronium
salts and malononitrile in water has been developed. Utilization
of -alkylisothiouronium salts as thiol equivalents
greatly broadens the application of the current method, and also
makes the reaction more environmentally friendly.
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© Georg Thieme Verlag Stuttgart ˙ New York
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