Efficient Synthesis of 3-Alkoxy-4,4-difluoropiperidines
Synlett
DOI: 10.1055/s-0029-1217533
Abstract
Fluorinated piperidines bearing an additional functional group
at the heterocyclic ring are important building blocks for use in
agrochemical or pharmaceutical chemistry. Therefore, for the first
time 3-alkoxy-4,4-difluoropiperidines were synthesized by deoxofluorination
of 3-alkoxy-4-piperidinones with morpholinosulfur trifluoride and
were selectively N- and O-deprotected. In addition, the
oxidation of 4,4-difluoro-3-hydroxy-1-trifluoroacetylpiperidine
resulted in the interesting 4,4-difluoro-3,3-dihydroxypiperidine.
[...]
© Georg Thieme Verlag Stuttgart ˙ New York
Get connected:
Table of contents | Abstract | Full text
