Ruthenium-Catalyzed Enantioselective Propargylation of Indoles with Propargylic Alcohols
Synthesis
DOI: 10.1055/s-0028-1083217
Abstract
Ruthenium-catalyzed enantioselective propargylation of 1-(triisopropylsilyl)-1-indoles with propargylic alcohols gives
the corresponding β-propargylated indoles in good yields
with high enantioselectivity. Reactions with 1-(1-naphthyl)prop-2-yn-1-ol
achieve the highest enantioselectivity (up to 95% ee).
[...]
© Georg Thieme Verlag Stuttgart ˙ New York
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