Mild and Practical Reductions of Prochiral Ketones to Chiral Alcohols Using the Chiral Boronic Ester TarB-H
Synthesis
DOI: 10.1055/s-0028-1083605
Abstract
Chiral alcohols are prepared under mild conditions in high enantiomeric
excesses using the tartaric acid derived chiral boronic ester TarB-H.
The phenylboronic acid was quantitatively recovered and recycled
using a simple extraction with sodium hydroxide and diethyl ether.
Aromatic and aliphatic secondary alcohols were prepared in up to
99% ee.
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© Georg Thieme Verlag Stuttgart ˙ New York
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