Straightforward Organocatalytic Enantioselective Protonation of Silyl Enolates by Means of Cinchona Alkaloids and Carboxylic Acids
Synlett
DOI: 10.1055/s-2008-1078260
Abstract
The combination of cinchona alkaloids and carboxylic acids provides
a very simple chiral proton source. By using this system, enantioselective
protonation of silyl enolates was achieved affording the corresponding
ketones in high yields and in up to 75% ee.
[...]
© Georg Thieme Verlag Stuttgart ˙ New York
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