Purification of highly polar compounds using Silica gel as solid support and methanol as main eluting agent always creates some complications.
Here we would discuss some commonly encountered problems and their resolution.
HRMS stands for the High Resolution Mass Spectrometry
This an advanced analytical technique
David Bylund discusses the development of novel antidepressants
Professor David Byland
Professor David Bylund is one of the most influential scientists working today in the field of the development of potential novel antidepressant agents and is especially interested in the field of adolescent depression. Professor Bylund’s laboratory is involved [...]
Kevin D. Hall
Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Book Review) DOI: 10.1021/jm800678c
Manfred E. Wolff
Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Book Review) DOI: 10.1021/jm800706c
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Target validation involves proving that DNA, RNA or a protein molecule is directly involved in a disease process and can be a suitable target for development of a new therapeutic drug.Pharmaceutical industry experts and analysts agree that drug target validation is the most critical challenge facing large pharmaceutical companies.¹
“Given the vast number of [...]
Driven by chemistry but increasingly guided by pharmacology and the clinical sciences, drug research has contributed more to the progress of medicine during the past century than any other scientiÞc factor. The advent of molecular biology and, in particular, of genomic sciences is having a deep impact on drug discovery.
Recombinant proteins and monoclonal antibodies have [...]
Oncology, at its most basic level, involves the diagnosis and treatment of cancer. The word oncology comes from the Greek word meaning “mass” or “bulk,” referring to tumors. A doctor who specializes in oncology is called an oncologist.
Oncology involves a huge range of study. Since cancer can occur in so many of the body’s systems, [...]
PEGylation: A Successful Approach to drug delivery
Francesco M. Veronese and Gianfranco Pasut
Department of Pharmaceutical Sciences, Padua University, Via F. Marzolo 5, 35128 Padua, Italy
PEGylation defines the modification of a protein, peptide or non-peptide molecule by the linking of one or more polyethylene glycol (PEG) chains. This polymer is non-toxic, non-immunogenic, non-antigenic, highly soluble [...]
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